Coronavirus et Aromathérapie


thérapeutique / lundi, juillet 27th, 2020

Quelques publications parues dans la presse scientifique tendent à prouver l’activité virucide in vitro  de certaines huiles essentielles sur la famille des coronavirus.

La dernière en date parue en juin 2020 dans Pubmed étudie l’effet virucide de l’huile essentielle de cajeput ( Mélaleuca cajuputi ) sur le Covid 19 :  « Evaluation of the Inhibitory Activities of COVID‐19 of Melaleuca cajuputi Oil Using Docking Simulation ». Cette étude émet une recommandation d’utiliser l’huile essentielle de cajeput pour prévenir les infections et limiter la propagation du SRAS-CoV-2.

Deux autres articles mettent en avant les propriétés de l’huile essentielle de Laurier Noble ( Laurus nobilis ) : « Phytochemical Analysis and in vitro Antiviral Activities of the Essential Oils of Seven Lebanon Species »  et  celles de l’huile essentielle d’Origan (Origanum Vulgare )  et de Cannelle « Virucidal Effectiveness Test – Coronavirus »

Il s’agit d’huiles essentielles des groupes des alcools monoterpeniques ( linalol,menthol, géraniol,bornéol, terpinéol,terpinène-4-ol ), des oxydes terpéniques ( 1-8 cinéol ) et  des phénols ( carvacrol , thymol, eugénol ) et  des aldéhydes aromatiques (aldéhyde cinnamique)

Des  huiles essentielles de ce groupe comme l’huile essentielle de Ravintsara ( Cinnamonum Camphora CT cinéol ) sont déjà utilisées favorablement dans  un certain nombre de pathologies virales comme la grippe, l’herpès, le zona, la mononucléose infectieuse ou la varicelle, en particulier en terme de prévention.

Références sur l’activité antivirale des huiles essentielles :

  1. Garozzo, A., Timpanaro, R., Bisignano, B., Furneri, P. M., Bisignano, G., & Castro, A. (2009). In vitro antiviral activity of Melaleuca alternifolia essential oil. Letters in applied microbiology, 49(6), 806-808.
  2. Reichling, J., Schnitzler, P., Suschke, U., & Saller, R. (2009). Essential oils of aromatic plants with antibacterial, antifungal, antiviral, and cytotoxic properties–an overview. Complementary Medicine Research, 16(2), 79-90.
  3. Schnitzler, P., Schon, K. and Reichling, J. (2001) Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture. Pharmazie 56, 343–347.
  4. Mohammad, A., & Mehmood, D. In Vivo Anti-Viral Effect of Melaleuca alternifolia (Tea Tree Oil) and Olea europaea (Olive Leaf Extract) on Vero Cell Adapted Avian Influenza Virus. Human Journals. Research Article December 2018 Vol.:14, Issue:1 Citation: Mohammad Danish Mehmood et al. Ijppr.Human, 2018; Vol. 14 (1): 7-19.
  5. Usachev, E. V., Pyankov, O. V., Usacheva, O. V., & Agranovski, I. E. (2013). Antiviral activity of tea tree and eucalyptus oil aerosol and vapour. Journal of aerosol science, 59, 22-30.
  6. Ankita, S., Chandra, S. S., & Arti, T. (2013). Phytochemical study and antimicrobial activities of cinnamomum camphora. World Journal of Pharmaceutical research Volume 3, Issue 2, 2287-2294
  7. Astani, A., & Schnitzler, P. (2014). Antiviral activity of monoterpenes beta-pinene and limonene against herpes simplex virus in vitro. Iranian journal of microbiology, 6(3), 149.
  8. Astani, A., Reichling, J., & Schnitzler, P. (2010). Comparative study on the antiviral activity of selected monoterpenes derived from essential oils. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 24(5), 673-679.
  9. Bisignano, B. (2009). Attività antivirale e studio del meccanismo d’azione di estratti di melaleuca alternifolia nei vonfronti del virus dell’influenza A. Area 06 – Scienze mediche. http://hdl.handle.net/10761/1767
  10. Blanchard, J. M. (2007). Cinnamomum camphora à cinéole (ravintsara), une plante au service de la prévention des infections nosocomiales en milieu hospitalier?. Phytothérapie, 5(1), 15-20.
  11. Carson, C.F., Ashton, L., Dry, L., Smith, D.W. and Riley, T.V. (2001) Melaleuca alternifolia (tea tree) oil gel (6%) for the treatment of recurrent herpes labialis. J Antimicrob Chemother 48, 450–451.
  12. Carson, C.F., Smith, D.W., Lampacher, G.J. and Riley, T.V. (2008) Use of deception to achieve double-blinding in a clinical trial of Melaleuca alternifolia (tea tree) oil for the treatment of recurrent herpes labialis. Contemp Clin Trials 29, 9–12.
  13. Galan, D. M., Ezeudu, N. E., …, & Malcolm, B. J. (2020). Eucalyptol (1, 8-cineole): an underutilized ally in respiratory disorders?. Journal of Essential Oil Research, 1-8.
  14. Garozzo, A., Timpanaro, R., Stivala, A., Bisignano, G., & Castro, A. (2011). Activity of Melaleuca alternifolia (tea tree) oil on Influenza virus A/PR/8: study on the mechanism of action. Antiviral research, 89(1), 83-88.
  15. Hamidpour, R., Hamidpour, S., Hamidpour, M., & Shahlari, M. (2014). Chemistry, Pharmacology and Medicinal Property of Camphor (Cinnamomum Camphora) Traditional Remedy with the History of Treating Several Diseases. Global Journal of Medical Research.
  16. Jean Michel Blanchard (2007). Cinnamomum camphora CT cineole (ravintsara), a plant to help prevent nosocomial infections in the hospital environment. International Journal of Clinical Aromatherapy Vol. 4 issue 1
  17. Li, X., Duan, S., Chu, C., Xu, J., Zeng, G., Lam, A. K. Y., … & Gu, H. (2013). Melaleuca alternifolia concentrate inhibits in vitro entry of influenza virus into host cells. Molecules, 18(8), 9550-9566.
  18. Li, Y., Xu, Y. L., … & Xu, P. P. (2017). Intranasal co-administration of 1, 8-cineole with influenza vaccine provide cross-protection against influenza virus infection. Phytomedicine, 34, 127-135.
  19. Loizzo, M. R., Saab, A. M., Tundis, R., Statti, G. A., Menichini, F., Lampronti, I., … & Doerr, H. W. (2008). Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species. Chemistry & biodiversity, 5(3), 461-470.
  20. Mansard, M., Laurain-Mattar, D., & Couic-Marinier, F. (2019). Huile essentielle de Ravintsara. Actualités Pharmaceutiques, 58(585), 57-59.
  21. Morales-Rico, C. L., … & González-Camejo, I. (2012). Composición química del aceite esencial de las partes aéreas de Melaleuca quinquenervia. Revista CENIC. Ciencias Químicas, 43, 1-2.
  22. Müller, J. et al. (2016). 1, 8-Cineole potentiates IRF3-mediated antiviral response in human stem cells and in an ex vivo model of rhinosinusitis. Clinical Science, 130(15), 1339-1352.
  23. Riley, T. V. (2005). Antiviral Activity of Tea Tree Oil–In Vitro and In Vivo. TV Riley – 2005 – academia.edu
  24. Siddique, S., et al. (2018). Chemical characterization, antioxidant and antimicrobial activities of essential oil from Melaleuca quinquenervia leaves. Indian Journal of Experimental Biology, 56, 686-693.
  25. Timpanaro, R., Garozzo, A., Bisignano, B., Stivala, A., Furneri, P. M., Tempera, G., & Castro, A. (2007). Inhibitory effect of Melaleuca alternifolia (tea tree oil) on influenza A/PR/8 virus replication. International Journal of Antimicrobial Agents, (29), S202-S203.
  26. Worth, H., ..& Dethlefsen, U. (2009). Concomitant therapy with Cineole (Eucalyptole) reduces exacerbations in COPD: a placebo-controlled double-blind trial. Respiratory research, 10(1), 69.
  27. Yang, Z., Wu, N., .. & Efferth, T. (2010). Anti-infectious bronchitis virus (IBV) activity of 1, 8-cineole: Effect on nucleocapsid (N) protein. Journal of Biomolecular Structure and Dynamics, 28(3), 323-330.
  28. Zamora, A. C. P. (2015). The Antiviral Properties of Melaleuca alternifolia concentrate (MAC) against West Nile virus (Doctoral dissertation, Griffith University).

 

 

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